NOVEL FORMULATION APPROCHES FOR GLYCOSIDES

Background: In our research we focused on Garcinia, Sennosides, Chrysophanol and Paclitaxel. The reason behind why we selected these plants was due to their unique and paramount effects and features such as (antineoplastic, antibacterial, antioxidant and hepatoprotective) activities.

Objectives: The aim of our study was to review many different research papers to relate them and differentiate between them, in other words to find similarities and differences in all methods to conclude which methods are considered advantageous over others, and what can be implemented now to provide optimal formulations. Also, for flourishing our knowledge as undergraduate students to be aware of different techniques to isolate as well as formulate plant derivatives.

Methods: Several techniques have been employed to improve and increase the absorption and bioavailability of these types of glycosides that were mentioned. Among them, solid gel formation, encapsulation, wet tablet granulation, and fabrication methods are utilized to formulate the Garcinia and sennoside glycosides. Other types of glycosides like Chrysophanol and Paclitaxel are formulated by hydrogel preparation, complexation of phospholipids with Chrysophanol, nanoparticle technique, and gel formulation for Paclitaxel.

Results: The bioavailability of the specific drugs were increased and the safest technique to formulate them were found.

Conclusion: different methods and new flourishing results were reviewed, compared and evaluated.

Keywords: Garcinia glycoside, Sennoside glycoside, Paclitaxel, Chrysophanol, formulation, solubility, bioavailability.